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. 2010 Mar;135(3):217–227. doi: 10.1085/jgp.200910309

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© 2010 Tadross and Yue

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Figure 1. — VDI analysis for detailed, multistate gating diagram. (A) Channel activation involves numerous closed states, with a single open state (top row). Inactivation (bottom row) can occur from any or all of the states in the top row. Equilibrium constants are as shown. (B and C) Simplified but equivalent state diagrams. (D) Behavior of the model in A if inactivation were to proceed exclusively from the open conformation. (D, 2) P_O (Eq. 1) and J_EFF (Eq. 3) as functions of V (mV). Parameters are as follows: Q₁(V) = 40 · exp(0.1 · (V + 10)), Q₂(V) = 20 · exp(0.08 · (V − 22.9)), Q₃(V) = 10 · exp(0.06 · (V − 21.9)), L(V) = 0.659 · exp(0.001 · (V − 41)), J_C1 = J_C2 = J_C3 = J_C4 = 0, and J_O = 4. (E) Behavior of the model in A if inactivation were to proceed exclusively from state C₃. Format and parameters identical to D, except J_C1 = J_C2 = J_C4 = J_O = 0 and J_C3 = 12. (F) Behavior of the model in A if inactivation were to proceed equally from states C₂, C₃, C₄, and O. Format and parameters as in D, except J_C1 = 0 and J_C2 = J_C3 = J_C4 = J_O = 3.5.