. 2010 Feb 8;11:22. doi: 10.1186/1471-2350-11-22

Table 2.

Nominally significant (P < 0.05) single-SNP genotypic tests of association with T2D age at diagnosis, ESRD age at onset, BMI on dialysis, and duration of T2D to ESRD onset.

Phenotype	Gene	Marker	Major/Minor alleles	MAF Case	1/1 Mean ± SD (n)	1/2 Mean ± SD (n)	2/2 Mean ± SD (n)	Dominant P-value	Additive P-value	Recessive P-value

ESRD age	IL6	Rs2069849	G/A	0.15	59.0 ± 10.5 (419)	59.8 ± 10.4 (140)	53.7 ± 10.4 (16)	0.896	0.581	0.040 (0.013)^a
Duration of T2D to ESRD	IL6	rs1554606	C/A	0.34	20.2 ± 13.7 (255)	19.7 ± 14.7 (245)	15.8 ± 13.0 (68)	0.247	0.052	0.007 (0.006)^a
T2D age	GCK1	rs2908296	C/A	0.35	41.6 ± 11.0 (235)	42.8 ± 12.2 (277)	38.0 ± 10.3 (63)	0.733	0.313	0.007 (0.014)^b
T2D age	GCK1	rs12673242	A/G	0.37	41.3 ± 11.4 (236)	43.2 ± 11.9 (258)	39.0 ± 11.2 (81)	0.38	0.606	0.023 (0.032)^b
ESRD age	GCK1	rs2908296	C/A	0.35	59.2 ± 10.0 (235)	59.4 ± 11.2 (277)	56.1 ± 8.7 (63)	0.632	0.157	0.027 (0.133)^a
ESRD age	GCK1	rs2971676	G/A	0.24	59.4 ± 10.4 (328)	59.0 ± 10.8 (217)	54.4 ± 8.8 (30)	0.328	0.092	0.02 (0.035)^a
ESRD age	GCK1	rs2971675	C/A	0.23	59.5 ± 10.5 (338)	58.7 ± 10.8 (210)	54.5 ± 8.4 (27)	0.2	0.065	0.033 (0.029)^a
ESRD age	GCK1	rs730497	G/A	0.2	58.9 ± 10.4 (367)	60.0 ± 10.6 (180)	51.5 ± 8.6 (25)	0.989	0.206	0.0004 (0.0006)^a
ESRD age	GCK1	rs2908289	G/A	0.27	58.5 ± 10.5 (315)	60.6 ± 10.7 (211)	55.1 ± 8.8 (49)	0.223	0.827	0.008 (0.129)^a
BMI	IGFBP1	rs1908751	C/T	0.33	29.8 ± 7.3 (254)	29.2 ± 6.7 (243)	31.6 ± 7.1 (60)	0.838	0.436	0.043 (0.067)^a
BMI	IGFBP3	rs10255707	G/A	0.04	29.9 ± 7.1 (511)	27.3 ± 5.4 (33)	23.5 ± 7.4 (2)	0.022 (0.120)^a	-	-
Duration of T2D to ESRD	IGFBP3	rs3110697	G/A	0.35	21.3 ± 15.7 (234)	18.5 ± 12.7 (270)	19.8 ± 14.2 (63)	0.027 (0.067)^a	0.055	0.586

Test models refer to the minor allele. *Only the dominant model was considered where the minor allele homozygote count was <10. Bold: P-values < 0.05. Unadjusted P values without parentheses and P values with parentheses adjusted for ^aT2D age- and ^bBMI.