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. 2010 Feb 26;6(2):e1000692. doi: 10.1371/journal.pcbi.1000692

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Deo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panels (a) and (b) correspond to NGT and IGT, respectively. Principal component #1 largely corresponds to pathways regulated by hepatic SLC25A13 activity, including glycolysis (lac, pyr) and gluconeogenesis (ala, ser), nucleotide biosynthesis (OMP, r1p, hxan, xan, xtsn, ncam), bile salt (gchol, tdchol) and citrulline (citr) accumulation, and NAD+/NADH balance by malate shuttling (glu, akg, mal). Principal component #2 largely corresponds to System A and L amino acid transport.