Table 1. Susceptibility to In Vivo Experimental Models of Infection in Mice Deficient in IL-1β, IL-18, or Inflammasome Components.

	IL-1β−/−	IL-18−/−	Caspase-1−/−	NLRP3−/−	ASC−/−	NLRC4−/−
Endotoxemia	Normal [74]	Lower [95],[96]	Lower [72],[73]	Lower [49]	Lower [48],[49]	ND
Turpentine	Lower [71],[74]	ND	Normal [70]	ND	ND	ND
E. coli	Normal [97]	Normal [97]	Higher [98]; Lower [97]	ND	ND	ND
Shigella	Higher [99]	Higher [99]	Higher [99]	ND	ND	ND
Salmonella	Higher [66]	Higher [66]	Higher [66]	Normal [67]	Normal [67]	Normal [67]
C. albicans	Higher [77],[87]	Higher [100]	Normal [78]; Higher [80]	Higher [79],[80]	ND	ND
S. aureus	Higher [68]	Higher [101]	ND	ND	Higher [68]	ND
C. trachomatis	ND	Normal [102]	Normal [76],[102]	ND	ND	ND
Listeria	Normal [103]	Lower [104]	Higher [105]	ND	ND	ND
Francisella	ND	ND	Higher [64]	ND	Higher [64]	ND
Legionella	ND	ND	Higher [106]	ND	ND	Higher [60],[106]
Influenza	Higher [69]	Lower [107]; Higher [108]	Higher [69]	Normal [69]	Higher [69]	ND

Lower (susceptibility): increased survival of the knock-out mice in the experimental model.

Higher (susceptibility): decreased survival of the knock-out mice in the experimental model.

ND, not done.