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. 2010 Feb 26;6(2):e1000863. doi: 10.1371/journal.pgen.1000863

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Chung, Bunz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Cdk2 directly phosphorylates at least two proteins, ATRIP and Cdc6, that directly regulate the G₂-M transition via the ATR-Chk1-Cdc25A pathway. The activity of Cdk1 is independently inhibited upon activation of the p53-p21 pathway, which is defective in many cancer cells. See text for additional details.