Figure 1. Phylogeny of Drosophila insulin-like peptides.

The evolutionary history of the seven DILP families from 12 fully sequenced Drosophila species inferred using the Neighbour-Joining method. Bootstrap replicate support percentages are shown next to the branches. The tree is drawn to scale, with branch lengths proportional to evolutionary distance computed using the JTT matrix-based method. 7 DILPs have remained present and clearly differentiated from each other during the more than 40 million years of evolution of Drosophilidae flies. D. grimshawi contains two DILP2 peptides (shaded in red).