. Author manuscript; available in PMC: 2010 Feb 26.

Published in final edited form as: Mamm Genome. 2009 Jul 21;20(7):424–436. doi: 10.1007/s00335-009-9200-y

Table 4. Conservation based analysis of non-synonymous coding SNPs.

The alteration, calculated subPSEC (substitution position-specific evolutionary conservation) score and probability of a deleterious consequence (Pdeleterious) are indicated for each allele. The calculations are based upon an alignment of evolutionarily related proteins, as described in Thomas et al., 2003 and Thomas & Kejariwal, 2004 and are available on-line http://www.pantherdb.org/tools/csnpScoreForm.jsp.

ALLELE	subPSEC	Pdeleterious	substitution
W-20J	-9.18434	0.99794	G599E
W-39J	-5.49221	0.92359	M627I
W-41J	-7.31019	0.98675	V831M
W-73J	-9.84495	0.99894	A609D