Table 2.
Examples of human reporter genes, radiolabeled probes and imaging modalities
| Class of reporter genesa | Gene | Reporter probes | Imaging modalities |
|---|---|---|---|
| Enzyme | HSV-1-tk | [123,124, 125,131I]FIAU; [18F]FEAU [18F]GCV; [18F]FPCV; [18F]FHBG | Scintigraphy, PET, SPECT |
| Luciferase | D-Luciferin | Bioluminescence | |
| TK2 | [124I]FIAU; [18F]FEAU | SPECT, PET | |
| GFP | Fluorochromes | Fluorescence camera | |
| Transporter | NIS | [123,124,131I]NaI; [99mTc]pertechnetate [186,188Re]perrhenate | Scintigraphy, PET, SPECT |
| NET | [123I]MIBG | Scintigraphy, SPECT | |
| Receptor | SSTR2 | [188Re]P829, [99mTc]P829 [111In]DTPA-D-Phe1-octreotide | Scintigraphy, PET |
| D2 receptor | [18F]FESP | PET |
a
Table adapted from Blasberg, 2003; Vassaux and Groot-Wassink, 2003; Briat and Vassaux, 2006 and Serganova et al., 2007.
D2, dopamine receptor 2; FEAU, 2′-fluoro-5-ethyl-1-β-D-arabinofuranosyluracil; FESP, Fluoroethylspiperone; FHBG, fluoro-3-(hydroxymethyl)butyl] guanine; FIAU, 2'deoxy-2′-fluoro-1-beta -d-arabinofuranosyl-5- iodo-uridine; FPCV, fluoropenciclovir; GCV, ganciclovir; MIBG, metaiodobenzylguanidine; NET, Norepinephrine transporter; SSTR2, Somatostatin subtype 2; TK2, Mitochondrial thymidine kinase2.