Table 3.

The inhibitory effects of B6 on the growth of mouse S180 and H22 cells in vivo

Groups	S180 xenograft model		H22 xenograft model
	Weight of tumour (g)	Inhibition (%)	Weight of tumour (g)	Inhibition (%)
Saline	1.24 ± 0.83	0	1.48 ± 0.37	0
B6 (40 mg·kg−1)	1.01 ± 0.61	18.7b	0.97 ± 0.51	34.5a
B6 (60 mg·kg−1)	0.78 ± 0.35	37.2a	1.03 ± 0.20	30.4b
B6 (80 mg·kg−1)	0.74 ± 0.32	40.1a	0.81 ± 0.40	45.3a
5-Fu (20 mg·kg−1)	0.52 ± 0.27	58.1a	0.49 ± 0.35	66.9a

B6 40, 60, 80 mg·kg⁻¹ or saline (i.e. control) was administered, intragastrically, to mice for 10 days, 24 h after the implantation of 1 × 10⁶ S180 or H22 cells. The sizes of the tumours that developed in the mice were measured in two dimensions (area) with calipers every day, and inhibition rates were determined after 10 days of drug administration. Data are presented as the mean ± SD of three independent experiments.

^aP < 0.01 versus control,

^bP < 0.05 versus control.

B6, N-(4, 5-dibromo-pyrrole-2-carbonyl)-L-amino isovaleric acid methyl ester.