Table 2.

Effects of 17β-oestradiol (E₂) and icariin on body weight, uterine index and biochemical parameters in ovariectomized mice

	Weight gain (% of change)	Uterus index (mg·g−1)	Serum Ca (mg·L−1)	Serum P (mg·L−1)	Urinary Ca/Cr (mg·mg−1)	Urinary P/Cr (mg·mg−1)
Sham	3.46 ± 0.93	1.69 ± 0.11	77.5 ± 1.4	63.1 ± 1.2	0.74 ± 0.05	11.32 ± 0.40
OVX	7.94 ± 0.59**	0.36 ± 0.06***	77.6 ± 1.0	58.9 ± 1.7	0.93 ± 0.09	9.23 ± 0.90
E2	2.41 ± 0.08∧∧∧	2.69 ± 0.18***∧∧∧	77.4 ± 1.2	63.7 ± 3.2	0.67 ± 0.04∧	9.82 ± 0.58
Icariin	5.23 ± 1.15	0.43 ± 0.04***	72.3 ± 1.6	69.6 ± 3.7∧	0.59 ± 0.03∧∧	8.66 ± 0.55*

^*P < 0.05,

^**P < 0.01,

^***P < 0.001 versus sham;

^∧P < 0.05,

^∧∧P < 0.01,

^∧∧∧P < 0.001 versus OVX.

Results are mean ± SEM, n= 7–8 mice per group.

OVX, ovariectomy.