Table 3.

Effects of 17β-oestradiol (E₂) and icariin on bone mineral density and bone strength at distal femur in ovariectomized mice

	Total BMD (mg·ccm−1)	Trabecular BMD (mg·ccm−1)	Polar SSI (mm3)
Sham	462 ± 11	461 ± 14	0.83 ± 0.11
OVX	393 ± 8***	386 ± 10**	0.32 ± 0.05**
E2	486 ± 17∧∧∧	494 ± 23∧∧∧	0.71 ± 0.06∧
Icariin	454 ± 7∧∧	443 ± 6.39∧	0.64 ± 0.04∧∧

^**P < 0.01,

^***P < 0.001 versus sham;

^∧P < 0.05,

^∧∧P < 0.01,

^∧∧∧P < 0.01 versus OVX.

Results are mean ± SEM, n= 7–8 mice per group.

BMD, bone mineral density; OVX, ovariectomy.