Figure 1.
Tetrandrine attenuated cardiac hypertrophy in vivo. (A) Gross hearts (top), representative whole hearts section (middle) and HE staining (bottom) at 8 weeks after aortic banding or sham operation(n= 6). (B–D) mRNA and protein expression levels of hypertrophic markers, ANP, BNP and Myh7, which were evaluated by real-time PCR (n= 3) and western blot (n= 4). *P < 0.01, compared with the vehicle-sham values. †P < 0.01, compared with the vehicle-AB values after AB. AB, aortic banding; ANP, atrial natriuretic peptide; BNP, B-type natriuretic peptide; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; HE, haematoxylin and eosin; Myh7, myosin heavy chain 7.