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. 2010 Jan 25;159(4):970–981. doi: 10.1111/j.1476-5381.2009.00605.x

Figure 3.

Figure 3

Tetrandrine attenuated the excess production of reactive oxygen species (ROS) in vitro and in vivo. (A) The time courses for the effect of tetrandrine on the generation of ROS induced by angiogensin II (Ang II). Cardiac myocytes were pretreated with 10 µM tetrandrine for 30 min and subsequently incubated with 1 µM Ang II for 120 min. Four parallel experiments were indicated. *P < 0.05, compared with control (0 Ang II). (B) Tetrandrine inhibited the pressure overload-induced increase of signal decay rate (n= 5). (C) Representative blots for the oxidation of myofibrillar proteins tropomyosin and α-sarcomeric actin and their quantitative analysis for each indicated group of mice. *P < 0.01, compared with the vehicle-sham values. †P < 0.01, compared with the vehicle-aortic banding (AB) values after AB.