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. 2010 Jan 25;159(4):970–981. doi: 10.1111/j.1476-5381.2009.00605.x

Figure 5.

Figure 5

Tetrandrine inhibited the calcineurin/NFAT signalling in response to hypertrophic stimuli. (A) NFAT activity was determined in cardiomyocytes treated with Ang II for the indicated times (n= 6). (B,C) Expression of the nuclear protein NFATc4 in the myocytes induced by Ang II in vitro and AB in vivo (n= 4). The concentration of tetrandrine used for in vitro experiments was 10 µM. *P < 0.01, compared with the vehicle-sham values. †P < 0.01, compared with the vehicle-AB values after AB. AB, aortic banding; Ang II, angiogensin II; NFAT, nuclear factor of activated T cells.