Table 1.
Echocardiographic data showed the effects of tetrandrine on cardiac hypertrophy induced by aortic banding
| Parameter | Vehicle-sham | Tetrandrine-sham | Vehicle-AB | Tetrandrine-AB |
|---|---|---|---|---|
| Number (n) | 10 | 10 | 8 | 9 |
| BW (g) | 27.5 ± 1.5 | 26.8 ± 2.1 | 26.6 ± 1.5 | 27.5 ± 1.2 |
| HW/BW (mg·g−1) | 4.66 ± 0.14 | 4.72 ± 0.13 | 8.11 ± 0.25* | 5.43 ± 0.31† |
| LW/BW (mg·g−1) | 4.54 ± 0.22 | 4.63 ± 0.12 | 7.69 ± 0.31* | 5.34 ± 0.15† |
| CSA (µm2) | 272 ± 30 | 269 ± 21 | 447 ± 28* | 325 ± 18† |
| SBP (mmHg) | 110.6 ± 1.8 | 114.5 ± 1.4 | 153.5 ± 4.2* | 143.2 ± 3.1* |
| HR (beats·min−1) | 471 ± 25 | 488 ± 25 | 456 ± 34 | 466 ± 30 |
| PWT (mm) | 1.23 ± 0.01 | 1.22 ± 0.02 | 2.42 ± 0.04* | 1.53 ± 0.03† |
| LVEDD (mm) | 3.55 ± 0.02 | 3.58 ± 0.02 | 5.54 ± 0.03* | 4.10 ± 0.01† |
| LVESD (mm) | 2.35 ± 0.03 | 2.37 ± 0.04 | 3.47 ± 0.02* | 2.66 ± 0.02† |
| LVSD (mm) | 0.61 ± 0.02 | 0.64 ± 0.03 | 1.51 ± 0.04* | 0.96 ± 0.03† |
| LVPWD (mm) | 0.65 ± 0.01 | 0.64 ± 0.06 | 1.32 ± 0.01* | 0.87 ± 0.05† |
| FS (%) | 52.7 ± 2.4 | 54.5 ± 3.1 | 32.4 ± 2.6* | 47.5 ± 1.5*† |
All values are mean ± SEM.
*
P < 0.01 was obtained for the vehicle-sham values.
†
P < 0.05 was obtained for the vehicle-AB values after AB.
AB, aortic banding; BW, body weight; CSA, cardiomyocyte cross-sectional area; FS, fractional shortening; HR, heart rate; HW, heart weight; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVPWD, left ventricular posterior wall, diastolic; LVSD, left ventricular septum, diastolic; LW, lung weight; PWT, posterior wall thickness; SBP, systolic blood pressure.