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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Jun 30;47(4):493–503. doi: 10.1016/j.yjmcc.2009.06.016

Figure 1.

Figure 1

Kappa agonist, U50488H, caused a greater decrease in cardiac inotropy in the failing heart. Acute U50488H administration decreased cardiac inotropy in Bio14.6 (■, dashed lines) and F1B (◆, solid lines) hamster hearts at (A) one and (B) nine months. This response was mediated by a PTX-sensitive G-protein as PTX pretreatment attenuated the effect of agonist concentrations that produced a 50% decrease from baseline function (0.5 and 1 μM for (C) one month F1B and (D) one and (F) nine months Bio14.6 and 2 and 5 μM for (E) nine months F1B). Data are mean±SEM. *p<0.05 vs. F1B or No PTX treatment. n=4–10 hamster hearts.