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Administration of the MOR-selective agonist fentanyl decreased cardiac contractility only at non-selective concentrations. Acute fentanyl administration only decreased cardiac inotropy in (A) one and (B) nine month Bio14.6 (■, dashed lines) and F1B (◆, solid lines) hamster hearts at 10 μM. The depressant effect of this high fentanyl concentration was not antagonized by PTX pretreatment at (C and D) one or (E and F) nine months. Data are mean±SEM. *p<0.05 vs. F1B. n=3–4 hamster hearts.
