Skip to main content
. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Jun 30;47(4):493–503. doi: 10.1016/j.yjmcc.2009.06.016

Figure 8.

Figure 8

Inhibition of cAMP accumulation by selective opioid receptor agonists. The KOR agonist U50488H (100 μM) inhibited the isoproterenol-induced accumulation of cAMP to a greater extent in left ventricular cardiomyocytes from Bio14.6 (open bars) compared to F1B (solid bars) hamsters, while the DOR agonist Tan-67 (100 μM) only inhibited cAMP accumulation in Bio14.6 cardiomyocytes. Agonist effects were blocked by the antagonists nor-BNI (100 μM) (KOR) and naloxone (100 μM) (non-selective OR). Data was normalized to protein content and represented as percentage of isoproterenol alone in same heart. No TX is basal [cAMP]. Data are mean±SEM. *p<0.05 vs. F1B with same treatment, #p<0.05 vs. agonist-treated cohort, †p<0.05 vs. Iso treatment alone. n=6–9 hamster hearts.