Skip to main content
. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Jun 30;47(4):493–503. doi: 10.1016/j.yjmcc.2009.06.016

Figure 9.

Figure 9

Selective KOR and DOR agonists decreased the amplitude of the systolic calcium transient. Cardiomyocytes were either incubated in Tyrode alone (no treatment, No TX), or agonists selective for the KOR (U50488H, 5 μM) or the DOR (DPDPE, 5 μM) with and without the antagonists nor-BNI (5 μM) or naloxone (NLX, 5 μM). The KOR agonist U50488H inhibited the electrically stimulated rise in intracellular calcium to a greater extent in left ventricular cardiomyocytes from Bio14.6 (open bars) compared to F1B (solid bars) hamsters, while the selective DOR agonist DPDPE only inhibited the amplitude of the calcium transient in Bio14.6 cardiomyocytes. Agonist effects were blocked by the antagonists nor-BNI (5 μM) (KOR) and naloxone (5 μM) (non-selective OR). Data represented as percentage of electrical stimulation alone (no treatment). Data are mean±SEM. *p<0.05 vs. F1B with same treatment, #p<0.05 vs. agonist-treated cohort, †p<0.05 vs. no treatment. n=9–11 hamster hearts.