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. Author manuscript; available in PMC: 2011 Feb 24.
Published in final edited form as: J Am Chem Soc. 2010 Feb 24;132(7):2378–2384. doi: 10.1021/ja9096219

Figure 6.

Figure 6

Water accessibility of amantadine-bound M2-TM at high pH in virus-envelope-mimetic lipid membranes. The water pathway through the pore is interrupted by amantadine. The five residues measured in this study are shown as sticks. The protein structure and amantadine position were determined from independent solid-state NMR distance experiments 38. The bilayer thickness is shown to scale with the helical bundle. The water molecules in the channel are for illustration only; their density, orientation, and diffusion rate are outside the scope of this study.