Table 4.

Simulation Study Results: Proportion out of 1000 simulated datasets for which there was a significant exposure effect

		Effect of Lipid Lowering Medication on LDL
	Method	5%	15%	25%	35%
		Type I Error
Scenario 1: exposure independent of treatment assignment and LDL	MESA imputed	0.031	0.039	0.048	0.038
	ignore	0.039	0.048	0.051	0.057
	adjust	0.043	0.047	0.054	0.047
	exclude	0.045	0.056	0.050	0.048
	censored normal	0.040	0.045	0.055	0.048
Scenario 2: exposure increases odds of treatment, but is independent of LDL	MESA imputed	0.045	0.030	0.036	0.049
	ignore	0.076	0.441	0.815	0.973
	adjust	0.322	0.409	0.388	0.436
	exclude	0.663	0.665	0.657	0.637
	censored normal	0.183	0.039	0.088	0.253
		Power
Scenario 3: exposure independent of treatment, but increases LDL	MESA imputed	0.896	0.903	0.905	0.911
	ignore	0.919	0.912	0.870	0.789
	adjust	0.904	0.919	0.907	0.914
	exclude	0.837	0.845	0.842	0.851
	censored normal	0.904	0.911	0.900	0.895
Scenario 4: exposure increases odds of treatment, and increases LDL	MESA imputed	0.819	0.842	0.826	0.819
	ignore	0.802	0.297	0.055	0.344
	adjust	0.361	0.335	0.318	0.240
	exclude	0.088	0.071	0.095	0.076
	censored normal	0.992	0.947	0.769	0.435