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. 2009 Jul 6;20(9):975–988. doi: 10.1089/hum.2009.028

FIG. 3.

FIG. 3.

Effect of PEGylation on liver and tumor transduction in LNCaP xenograft model after systemic injection of replication-competent adenovirus. (a) PEGylation with 20-kDa PEG but not with 5-kDa PEG reduces transduction of liver in nu/nu mice bearing LNCaP tumor xenografts. Mice (n = 7 per group) with established tumors (30 days; average volume, 202 mm3) were injected intravenously with a single dose of 5 × 1010 VG of Ad-GL or PEGylated Ad-GL in 100 μl of PBS. Mice were imaged for luciferase expression on days 1 and 3 after virus injection. (b) Quantification of the effect of PEGylation on the levels and kinetics of luciferase expression in mice bearing LNCaP tumors after injection of Ad-GL. The luminescence signal in liver and tumor of mice was measured and quantified on days 1, 3, 7, 12, 16, 26, and 41 after Ad-GL injection. Data are shown as means and SD. Color images available online at www.liebertonline.com/hum.