Table 2.

Tibial epiphysis cortical and trabecular bone volume and density

	Leptin intact	Leptin impaired		Intact v. impaired
	WT (n=11)	ob/ob (n=6)	db/db (n=5)
Cortical Bone
Bone volume, BVcort (cm3)	0.20 ± 0.02	0.17 ± 0.03	0.20 ± 0.01	NS, p = 0.56
Total epiphyseal volume, TV (cm3)	0.62 ± 0.06	0.58 ± 0.11	0.60 ± 0.03	NS, p = 0.77
Relative bone volume (BVcort/TV)	0.33 ± 0.02	0.29 ± 0.01	0.33 ± 0.01	NS, p = 0.41
Bone density (mg hydroxyapatite/cm3)	1118 ± 9	1074 ± 13	1102 ± 17	NS, p = 0.06
Trabecular bone
Bone volume, BVtrab (cm3)	0.17 ± 0.02	0.23 ± 0.04	0.22 ± 0.01	NS, p = 0.09
Total volume, (TVtrab = TV - BVcort) (cm3)	0.42 ± 0.04	0.42 ± 0.08	0.41 ± 0.02	NS, p = 0.93
Relative bone volume (BVtrab/ TVtrab)	0.43 ± 0.02	0.57 ± 0.03	0.53 ± 0.03	** p <0.001
Bone density (mg hydroxyapatite/cm3)	1039 ± 12	1020 ± 3	1036 ± 9	NS, p = 0.34

Values are presented as group means ± standard error of the mean.

^*p<0.05,

^**p<0.01.