Table 2.
Listed are a subset of upregulated proteins in OVE26 type 1 diabetic mouse tubules. The proteins were selected from Ingenuity Analysis as being related to diabetes, metabolism or oxidative stress.
| RefSeq Accession | Protein | Fold increase Diabetic* | Ontology (top findings IPKB) | Citation |
|---|---|---|---|---|
| NP_033414 | Transketolase (TKT) | 1.7 | Regulates and regulated by D-glucose, metabolic process | [74, 75] |
| NP_032416 | Interferon regulatory factor 1 (IRF1) | ∞ | Experimentally-induced diabetes | [76, 77] |
| NP_034626 | Inhibitor of DNA binding 2 (ID2) | ∞ | Regulated by TGFβ1 | [78, 79] |
| NP_033506 | upstream stimulatory factor 1 (USF1) | ∞ | Regulated by TGFβ1, D- glucose, Insulin | [80, 81] |
| NP_035790 | Thioredoxin (TXN) | ∞ | Diabetes, oxidative stress response | [82] |
*
- ∞ indicates no peptides detected for this protein in FVB control mouse tubule lysates. Bold highlight indicates further validation was confirmed by immunoblot.