Table 1.
The detailed information of 30 compounds active against neuroblastoma cells.
| Drugs | Mechanism of action | References | FDA approved |
Current NB therapy |
Current NB clinical trial |
Current pediatric clinical trial |
Current adult clinical trial |
|---|---|---|---|---|---|---|---|
| 17AAG* | Inhibits Hsp90 | 43 | − | − | + | + | + |
| 5-azacytidine | Inhibits transcription and translation | + | − | − | − | + | |
| Alsterpaullone | Inhibits CDK1/Cyclin B | 44 | − | − | − | − | − |
| Amonafide | Inhibits topoisomerase 2 | 45 | − | − | − | − | + |
| Arsenic trioxide | PML/RAR alpha degradation | 46 | + | − | + | + | + |
| Bortezomib analog* | Inhibits the proteasome | − | − | − | − | − | |
| Bortezomib* | Inhibits the proteasome | 47 | + | − | + | + | + |
| Camptothecin* | Inhibits topoisomerase 1 | 48 | − | − | + | + | + |
| CDDO-ME* | Inhibits AKT, NFkB, Notch1, mTOR, STAT3, and JNK |
24; 32 25 30 | − | − | − | − | + |
| Colchicine* | Inhibits microtubule polymerization |
49 | + | − | − | − | − |
| Cucurbitacin I* | Inhibits STAT3 activation | 10 38 | − | − | − | − | − |
| Dactinomycin* | Intercalates with DNA | 50 | + | − | − | + | + |
| Daunorubicin* | Inhibits topoisomerase 2 | + | − | − | + | + | |
| Didemnin B | Inhibits protein synthesis by binding to human ef1A |
51 | − | − | − | − | − |
| Doxorubicin* | Inhibits topoisomerase 2 | + | + | + | + | + | |
| Echinomycin | Inhibits topoisomerase 2 | 52 | − | − | − | − | − |
| Epoxy anthraquinone derivative* |
Unknown | − | − | − | − | − | |
| Etoposide | Inhibits topoisomerase 2 | 53 | + | + | + | + | + |
| Helenalin* | Unknown | − | − | − | − | − | |
| Maytansine* | Inhibits microtubule polymerization |
54 | − | − | − | − | − |
| Mitoxantrone* | Inhibits topoisomerase 2 | 40 | + | − | − | + | + |
| Paclitaxel* | Inhibits microtubule depolymerization |
55 | + | − | − | + | + |
| PD 0332991 (Pfizer Inc) | Inhibits CDK4/6 | 15 | − | − | − | − | + |
| Perezone | Unknown | − | − | − | − | − | |
| Teniposide | Inhibits topoisomerase 2 | 53 | + | − | − | + | + |
| Tetrandrine | Induces CDK inhibitor p21; induction of cyclin D1 |
56 | − | − | − | − | − |
| Thioguanine | Inhibits transcription and translation | + | − | − | + | + | |
| Topotecan* | Inhibits topoisomerase 1 | 53 | + | + | + | + | + |
| Valrubicin | Inhibits topoisomerase 2 | 57 | + | − | − | − | + |
| Vincristine* | Inhibits microtubule polymerization |
58 | + | + | + | + | + |