. Author manuscript; available in PMC: 2011 Mar 15.

Published in final edited form as: Blood Cells Mol Dis. 2010 Jan 27;44(3):191–197. doi: 10.1016/j.bcmd.2009.12.010

Table 2.

Three miRNAs that are associated with overall survival of the 32 ALL patients

miRNAs	Cox Regression Coefficient^a	Hazard Ratio	p Value^b
Increased expression associated with a good outcome
miR-221	−0.619053	0.538454	0.0379821
Increased expression associated with poor outcome
miR-146a	0.525527	1.69135	0.0388068
miR-181a/c	0.52796	1.69547	0.0111003

Cox regression models were used to assess the association between expression of individual miRNA precursors and overall survival. The 3 miRNAs with a significant association (P<0.05) constituted the outcome signature. A negative regression coefficient (which corresponds to a hazard ratio of <1) indicates that increased expression was associated with a good outcome, and a positive coefficient (which corresponds to a hazard ratio of >1) indicates that increased expression was associated with a poor outcome.

p values show the significance of the Cox regression coefficient and were calculated.