Table 3.
| a. Haplotype analysis of 5′ region of GABRR1 and 3′ region of GABRR2. | ||||
|---|---|---|---|---|
| rs914479 nucleotide1 |
rs282129 nucleotide1 |
DSM-IV3 | Early onset3 | COGA3 |
| T | G | 0.008 | 0.019 | 0.007 |
| T | A2 | 0.08 | 0.07 | 0.43 |
| C2 | G | 0.33 | 0.12 | 0.34 |
| C2 | A2 | 0.11 | 0.35 | 0.023 |
| Global test | 0.016 | 0.03 | 0.014 | |
| b. Haplotype analysis of GABRR2. | ||||
|---|---|---|---|---|
| rs282121 nucleotide1 |
rs1094441 nucleotide1 |
DSM-IV3 | Early onset3 |
COGA3 |
| T2 | A2 | 0.84 | 0.30 | 0.24 |
| T2 | G | 0.035 | 0.014 | 0.012 |
| C | A2 | 0.044 | 0.17 | 0.002 |
| C | G | 0.37 | 0.25 | 0.67 |
| Global test | 0.07 | 0.05 | 0.005 | |
Nucleotides are shown on the human genome strand.
Minor allele.
P-value of UNPHASED PDTsum statistic for association between the haplotype and alcohol dependence. P ≤ 0.05 is in bold.