Table 1.
Biometric and myocardial contractile features of control and STZ‐induced diabetic mice
| Mouse group | Control | Diabetic | Diabetic + siRNA‐RAGE | Diabetic + siRNA‐NT |
|---|---|---|---|---|
| Body weight (g, pre‐STZ) | 23.6 ± 0.2 | 23.3 ± 0.4 | 23.2 ± 0.5 | 22.9 ± 1.1 |
| Body weight (g, at killing) | 27.1 ± 0.3 | 22.6 ± 0.3* | 23.1 ± 0.6 | 22.7 ± 1.0 |
| Heart weight (mg) | 194 ± 5 | 153 ± 5* | 151 ± 7* | 150 ± 6* |
| Heart/weight (mg/g) | 7.17 ± 0.16 | 6.81 ± 0.22 | 6.52 ± 0.15 | 6.64 ± 0.10 |
| Liver weight (mg) | 1466 ± 61 | 1404 ± 48 | 1397 ± 63 | 1389 ± 71 |
| Liver/body weight (mg/g) | 54.2 ± 2.3 | 62.4 ± 2.4* | 60.3 ± 1.4* | 61.3 ± 1.9* |
| Kidney weight (mg) | 409 ± 7 | 420 ± 8 | 428 ± 5 | 411 ± 10 |
| Kidney/body weight (mg/g) | 15.1 ± 0.3 | 18.7 ± 0.5* | 18.5 ± 0.3* | 18.2 ± 0.4* |
| Fasting blood glucose (mmol/l) | 5.95 ± 0.14 | 21.0 ± 0.83* | 19.1 ± 0.93* | 18.5 ± 1.21* |
| Serum level of AGE (U) | 9.5 ± 0.4 | 17.1 ± 0.5* | 15.6 ± 0.7* | 15.3 ± 0.8* |
| Heart rate (ex vivo, bpm) | 231 ± 47 | 259 ± 51 | 263 ± 48 | 237 ± 64 |
| LVDP (mmHg) | 73.2 ± 5.6 | 37.4 ± 4.8* | 57.5 ± 4.3# | 33.4 ± 4.6* |
| +dP/dt (mmHg/sec.) | 3453 ± 511 | 1087 ± 187* | 2750 ± 213# | 997 ± 102* |
| −dP/ dt (mmHg/sec.) | −2304 ± 168 | −1001 ± 184* | −1939 ± 117# | −1039 ± 103* |
siRNA‐NT: siRNA non‐target control, mean ± S.E.M., n= 19 mice per group, *P < 0.05 versus control group; # P < 0.05 versus diabetic group.