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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Biol Psychiatry. 2009 Nov 22;67(6):592–594. doi: 10.1016/j.biopsych.2009.10.004

Fig. 1.

Fig. 1

Fluoxetine potentiates methylphenidate-induced gene regulation and behavior. (a) Illustrations of film autoradiograms depict expression of zif 268 in the striatum on the middle striatal level for rats that received a single injection of vehicle (V), methylphenidate (MP, 5 mg/kg, i.p.) or fluoxetine (FLX, 5 mg/kg), or a combination of methylphenidate+fluoxetine. (b) Mean density values (mean±SEM) for c-fos and zif 268 expression in the nucleus accumbens (left) and middle striatum (right) are given for rats that were treated with vehicle, methylphenidate, fluoxetine, or methylphenidate+fluoxetine (n=5-7). (c) For comparison, zif 268 expression in the striatum after acute cocaine administration (25 mg/kg; 19) is shown. (d) Ambulation (left), rearing (middle) and stereotypy counts (right) are given for animals that received the above methylphenidate and/or fluoxetine treatments and were then tested in a novel open field (40 min). Fluoxetine selectively potentiated methylphenidate-induced stereotypies. * P<0.05, ** P<0.01, *** P<0.001, vs. vehicle controls or as indicated.