Table 1.

Fluoxetine potentiates methylphenidate-induced gene regulation in the striatum. Mean density values (mean±SEM) for c-fos (top) and zif 268 expression (bottom) in the striatum on rostral, middle and caudal levels are given for rats that were treated with vehicle, methylphenidate, fluoxetine, or methylphenidate+fluoxetine (n=5-7).

	striatum	vehicle	methyl- phenidate	fluoxetine	methylphenidate +fluoxetine
c-fos	rostral	2.4 ± 0.5	8.8 ± 0.3 ***	3.6 ± 0.3	14.5 ± 1.6 *** ††† •••
	middle	3.5 ± 0.6	11.3 ± 0.8 ***	2.2 ± 0.8	22.1 ± 1.8 *** ††† •••
	caudal	2.9 ± 0.4	12.0 ± 1.7 ***	2.7 ± 0.5	20.4 ± 1.8 *** ††† •••
zif 268	rostral	18.8 ± 0.6	30.2 ± 0.7 ***	21.4 ± 1.0	37.6 ± 2.2 *** ††† •••
	middle	17.5 ± 0.5	31.7 ± 1.6 ***	19.0 ± 0.9	40.5 ± 1.8 *** ††† •••
	caudal	13.8 ± 1.0	28.4 ± 1.9 ***	15.5 ± 0.9	35.3 ± 2.5 *** ††† ••

^***P<0.001, vs. vehicle

^†††P<0.001, vs. fluoxetine

^••P<0.01

^•••P<0.001, vs. methylphenidate