. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: J Appl Toxicol. 2010 Mar;30(2):172–182. doi: 10.1002/jat.1484

Table 3.

Metabolite concentrations as detected by NMR in different age group of SD rats after treatment with different doses of cisplatin

Age (days)	Metabolite	Control	3 mg kg⁻¹ CP 24 h	3 mg kg⁻¹ CP 48 h	3 mg kg⁻¹ CP 72 h	6 mg kg⁻¹ CP 24 h	6 mg kg⁻¹ CP 48 h	6 mg kg⁻¹ CP 72 h
25	Oxoglutarate	59 ± 21	37 ± 2.9^*	34 ± 12^*	43 ± 27	57 ± 7.9	30 ± 13^*	19 ± 20^*
	Acetate	76 ± 110	54 ± 59	80 ± 77	84 ± 59	9.3 ± 5.3^*	22 ± 8.2^*	93 ± 54
	Alanine	11 ± 14	6.88 ± 2.53	6.62 ± 3.78	8.9 ± 5.7	4.30 ± 0.76	6.32 ± 1.71	9.61 ± 6.08
	Citrate	170 ± 49	124 ± 45	134 ± 20	108 ± 73	123 ± 23^*	74 ± 44^*	67 ± 82
	Fumarate	2.10 ± 1.27	1.35 ± 0.04^*	1.31 ± 0.24^*	1.35 ± 0.60	1.76 ± 0.22	0.80 ± 0.07^*	0.58 ± 0.23^*
	Glucose	5.4 ± 1.3	9.8 ± 2.4	6.4 ± 0.8	6.8 ± 2.1	9.0 ± 2.6	11 ± 10	8.6 ± 4.0
	Glutamate	0.99 ± 0.29	1.97 ± 0.92	1.38 ± 0.68	1.6 ± 0.18^*	1.55 ± 0.39	1.37 ± 0.25^*	1.39 ± 0.20^*
40	Oxoglutarate	118 ± 19	79 ± 34	82 ± 25	90 ± 36	110 ± 36	51 ± 35^*	46 ± 36^*
	Acetate	7.4 ± 12	3.6 ± 2.0	10 ± 7.7	27 ± 4.7^*	18 ± 16	32 ± 23	92 ± 43^*
	Alanine	1.77 ± 0.97	1.63 ± 0.55	3.06 ± 1.80	11 ± 13	3.04 ± 1.47	5.2 ± 2.1^*	20 ± 5.4^*
	Citrate	167 ± 37	78 ± 54^*	65 ± 25^*	127 ± 73	66 ± 9.8^*	60 ± 53^*	57 ± 61^*
	Fumarate	1.68 ± 0.34	0.98 ± 0.57	1.26 ± 0.57	1.47 ± 0.67	1.09 ± 0.32^*	0.64 ± 0.37^*	0.50 ± 0.33^*
	Glucose	7.0 ± 2.0	6.3 ± 2.7	9.4 ± 1.5^*	79 ± 124	12 ± 3.0^*	17 ± 4.3^*	89 ± 68
	Glutamate	0.99 ± 0.29	1.88 ± 0.40^*	1.33 ± 0.26	1.88 ± 1.22	2.9 ± 1.2	1.32 ± 0.36	1.89 ± 0.31^*
80	Oxoglutarate	90 ± 25	57 ± 12.4^*	15 ± 12^*	45 ± 12^*	45 ± 25^*	38 ± 45	12 ± 9.0^*
	Acetate	7.7 ± 12	12 ± 4.2	36 ± 15	72 ± 29^*	14 ± 10	73 ± 89	50 ± 48^*
	Alanine	1.97 ± 0.88	2.18 ± 0.30	4.01 ± 0.52^*	20 ± 7.2^*	3.1 ± 2.6	14 ± 19	11 ± 7.4
	Citrate	94 ± 24	25 ± 9.9^*	14 ± 17^*	17 ± 6.5^*	18 ± 9.1^*	16 ± 18^*	6.5 ± 6.1^*
	Fumarate	0.80 ± 0.30	0.40 ± 0.06^*	0.26 ± 0.12^*	0.27 ± 0.13^*	0.49 ± 0.35	0.99 ± 1.57	0.18 ± 0.16^*
	Glucose	9.7 ± 1.8	11 ± 2.2	10 ± 5.2	135 ± 20^*	19 ± 14	71 ± 92	66 ± 61
	Glutamate	0.93 ± 0.44	2.02 ± 0.28^*	1.52 ± 0.51	1.95 ± 0.51^*	3.7 ± 3.6	13 ± 23	2.56 ± 1.64

The results are means ± SEM for four rats in each age group.

Significantly different from control for each age group (P < 0.05).