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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Med Res Rev. 2010 Mar;30(2):171–257. doi: 10.1002/med.20155

Table II.

A summary of boronic acid-based sensors

Compound No. Sensor Target Binding Constants (Ka) Study conditions
19, 20a–c Glucose 23 M−1 to 37 M−1 λex: 460 nm, λem: 510 nm, in phosphate buffer, pH = 7.4
21, 20a–c Glucose 14 M−1 λex: 414 nm, λem: 644 nm, in phosphate buffer, pH = 7.4
22, 20a–c Glucose around 100 M−1 λex: 460 nm, λem: 604 nm, in phosphate buffer, pH = 7.4
26 gluconic acid 107 M−1 UV studies in 75% methanol/HEPES buffer, pH = 7.4
27 sorbitol 1060 M−1 (5 fold over fructose) λex = 365 nm, λem = 420 nm, in50% MeOH/aqueous phosphate buffer, pH = 7.4
28a glucose 1472 M−1 (43 fold over fructose) λex = 370 nm, λem = 430 nm, in aqueous phosphate buffer, pH = 7.4
30 ribose 2400 M−1 (24 fold over fructose, 8 fold over galactose, and 12 fold over glucose) λex = 565 nm, λem = 597 nm, in90% DMSO/phosphate buffer, pH = 7.4
34 D-mannitol enantioselectivity (KR/KS) of 1:20000 in binding with D-mannitol λex = 373 nm, λem = 421 nm, in52% CH3OH/aqueous buffer, pH = 8.3.
37 D-glucose D-glucose (24800 ± 1200 M 1) to L-glucose (11900 ± 1600 M 1) λex = 285 nm, λem = 480 nm, in50% CH3OH/water, pH =11.7
44 heparin Heparin (3 × 107 M−1) over dextran (3 × 103 M−1), hyaluronic acid (2 × 103 M−1), chondroitin (4 × 106 M−1), and ovalbumine (1 × 106 M−1). λem = 510 nm, in HEPES buffer