Table 1.
Population, Haplotype and Diplotype Description.
| 1st Chromosome | 2nd Chromosome | Diplotype | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease Status |
Age |
Gender |
Braak Stage |
Amyloid Plaque |
Post-Mortem Interval |
APOE |
rs11556505 |
rs59007384 |
rs157584 |
rs741780 |
rs449647 |
Haplotype |
rs11556505 |
rs59007384 |
rs157584 |
rs741780 |
rs449647 |
Haplotype |
H1 + or − |
| AD | 82 | Male | IV | Frequent | 8:00 | 4/4 | C | G | C | T | A | H6 | T | T | T | T | A | H2 | H1− |
| AD | 84 | Female | VI | Sparse | 5:00 | 3/4 | C | T | T | T | A | H3 | T | T | T | T | T | H5 | H1− |
| AD | 76 | male | VI | Frequent | 4:30 | 4/4 | C | T | T | T | A | H3 | T | T | T | T | A | H2 | H1− |
| AD | 78 | male | VI | Frequent | 7:15 | 4/4 | C | T | T | T | A | H3 | T | T | T | T | A | H2 | H1− |
| AD | 87 | Female | VI | Moderate | 5:00 | 3/3 | C | G | C | C | A | H1 | C | G | T | T | A | H4 | H1+ |
| AD | 78 | male | VI | Moderate | 4:15 | 3/4 | C | G | C | C | A | H1 | C | T | T | T | A | H3 | H1+ |
| AD | 93 | Female | VI | Sparse | 6:30 | 3/4 | C | G | C | C | A | H1 | T | T | T | T | A | H2 | H1+ |
| AD | 60 | Female | IV | Moderate | 7:30 | 3/3 | C | G | C | C | A | H1 | C | G | C | C | A | H1 | H1+ |
| Control | 93 | Male | IV | Sparse-Moderate | 4:00 | 3/3 | C | G | C | C | A | H1 | C | G | T | T | T | H7 | H1+ |
| Control | 89 | Female | III | Sparse | 5:30 | 3/3 | C | G | C | C | A | H1 | T | T | T | T | T | H5 | H1+ |
| Control | 94 | Female | III | Sparse | 6:00 | 3/3 | C | G | C | C | A | H1 | T | T | T | T | T | H5 | H1+ |
| Control | 86 | Male | II | > Sparse | 2:30 | 3/3 | C | G | C | C | A | H1 | C | G | T | T | A | H4 | H1+ |
| Control | 86 | Male | II | > Sparse | 2:30 | 3/3 | C | G | C | C | A | H1 | C | G | T | T | A | H4 | H1+ |
| Control | 79 | Female | II | Moderate | 3:00 | 3/4 | C | G | C | C | A | H1 | T | T | T | T | A | H2 | H1+ |
| Control | 87 | Female | II | None | 3:45 | 3/3 | C | G | C | C | A | H1 | C | G | C | C | A | H1 | H1+ |
| Control | 94 | Male | IV | Sparse | 6:00 | 3/3 | C | G | C | C | A | H1 | C | G | C | C | A | H1 | H1+ |
The halotype anlysed includes 5 SNPs: rs 11556505, rs59007384, rs157584, rs741780, rs449647. There are a total of 7 different haplotypes. Haplotype number was assigned according to its ranking in frequency. The most common H1 haplotype is associated with increased AD risk (OR: 3.00, 95% Cl: 1.35 – 6.68).