. Author manuscript; available in PMC: 2010 Feb 27.

Published in final edited form as: Invest New Drugs. 2008 Jul 11;27(1):53–62. doi: 10.1007/s10637-008-9154-z

Table 1.

Doses of bortezomib, carboplatin and etoposide administered every 21 days

Dose level	Bortezomib (mg m⁻² dose⁻¹)^a	Carboplatin AUC (day1)	Etoposide (mg m⁻² dose⁻¹; day 1, 2, 3)
Days 1, 4, 8, and 11
−1	0.75	AUC 4	75
1	1	AUC 5	100
1a	0.75	AUC 5	75
Days 1 and 8
1b	1	AUC 5	75
2	1	AUC 5	100

Dosing of bortezomib reduced from twice weekly to once weekly in cohorts 1b and 2 due to excessive toxicity noted in cohorts 1, −1 and 1a