Table 2.

Cytogenetic analyses in patients with anaplastic thyroid cancer

References	Patients (n)	Cell lines (n)	Gains	Losses	Both	Chromosomes
Jenkins et al. (1990)	2	–				Complex clonal karyotype; loss of eight (both); x; y −2, −4, −8, −9, +11, −13, +14, −14, +15, −17, −19, −20, −21, −22, −x, −y
Hemmer et al. (1999)	13	–	10/13	3/13	2/13	+7p (31%); +8q (23%); +9q (23%)
Wilkens et al. (2000)	9	2				Gains in 14 chromosomes; losses in eight chromosomes; most common: 5p amplified; 8p, 8q gains or losses
Kitamura et al. (2000)	21					Allelic losses 16/21; Losses: 1q (40%); 9p (58%); 11p (33%); 11q (33%); 17p (44%); 17q (43%); 19p (36%); 22q (38%)
Wreesmann et al. (2002)	15	–				Early Gains: 5, 8, 19; losses: 8, 22; intermediate: gains:1, 6, 9, 17, 20; losses: 1, 2, 6, 13 late: gains: 3p, 11q; losses: 5q
Miura et al. (2003)	10	1	5/10	2/10		Gains: 1, 4, 5, 6, 7, 10, 14, 16, 19, 20, 21, x; losses: 3p; 9q
Rodrigues et al. (2004)	7	–				Gains in all chromosomes; losses less common; high amplification in: 3p, 5p, 6p, 9p, 12p, 14q, 18p
Rodrigues et al. (2007)	–	3				Amplifications: 3q24; 5p; 7p; 7q; 12p; 14q; 20
Lee et al. (2007)	–	8				Frequent: gains: 8q; 11q; 19; 20q; losses: 4q; amplification: 8q
Lee et al. (2008)	27					Gains: 1q21; 6p22-p21; 7q11.22-11.23; 11q13; 12q13; 16p11.2; 17q21; 19p13; 19q13. 1-q13.2; 20q11.2; 20q13.12; 22q11.21; 22q.13.1 Losses: 4q12-q13.1; 4q28.3; 13q21.2-q21.31