Table 4.

Proteins expression in anaplastic thyroid carcinoma

	Overexpressed		Underexpressed
Protein	Cell line	Tumor	Cell line	Tumor	References
Transcription
PPARG	X	X			Hayashi et al. (2004), Aiello et al. (2006) and Copland et al. (2006b)
HNF-1α	X	X			Xu et al. (2008)
NKX2-1				X	Bejarano et al. (2000), Miettinen & Franssila (2000) and Zhang et al. (2006)
FOXE1				X	Zhang et al. (2006)
Pax 8				X	Zhang et al. (2006)
CBX7			X	X	Pallante et al. (2008)
Id1		X			Kebebew et al. (2004)
YBX1		X			Ito et al. (2003b)
HMGI(Y)	X				Scala et al. (2000)
FOSL1		X			Chiappetta et al. (2000)
C-myc		X			Kurihara et al. (2004)
Signaling pathway
EGFR	X	X			Ensinger et al. (2004), Schiff et al. (2004), Wiseman et al. (2007b) and Elliott et al. (2008)
CXCR4	X	X			De Falco et al. (2007)
pAKT1		X			Santarpia et al. (2008)
pERK		X			Santarpia et al. (2008)
Mitosis
Aurora kinases	X	X			Sorrentino et al. (2005) and Ulisse et al. (2006)
TACC3			X		Ulisse et al. (2007)
Kα1 tubulin		X			Takano et al. (2001)
Topoisomerase-11		X			Wiseman et al. (2007a)
Proliferation
MKI67		X			Tallini et al. (1999), Ito et al. (2003b), Saltman et al. (2006) and Wiseman et al. (2007a)
OEATC-1	X				Mizutani et al. (2005)
RBBP4	X	X			Pacifico et al. (2007)
Cell cycle
Cyclin D1		X			Wang et al. (2000), Kurihara et al. (2004), Wiseman et al. (2007b) and Lee et al. (2008)
Cyclin D3	X	X			Baldassarre et al. (1999)
Cyclin E		X			Wiseman et al. (2007b)
p21				X	Saltman et al. (2006)
p27			X	X	Baldassarre et al. (1999) and Tallini et al. (1999)
Apoptosis
IAPs	X	X			Ito et al. (2003a) and Tirro et al. (2006)
BCL2				X	Saltman et al. (2006) and Wiseman et al. (2007a)
DJ-1	X	X			Zhang et al. (2008)
NF-κB	X				Starenki et al. (2004) and Meng et al. (2008)
αB-crystallin			X	X	Mineva et al. (2005)
LCN2	X	X			Iannetti et al. (2008)
Adhesion
Cadherin 1, type 1, E-cadherin (epithelial)			X	X	Dahlman et al. (1998), Husmark et al. (1999), Motti et al. (2005) and Wiseman et al. (2006, 2007a)
Catenin (cadherin-associated protein), beta 1		X			Wiseman et al. (2007b)
ILK1	X	X			Younes et al. (2005)
FAK		X			Kim et al. (2004)
Tumor suppressor
TP53		X			Saltman et al. (2006) and Wiseman et al. (2007a)
Rb			X		Motti et al. (2005)
p16				X	Lee et al. (2008)
PTEN				X	Hou et al. (2008)