| Transcription |
|
|
|
| PPARG |
TZDs |
GW9662; siRNA |
Hayashi et al. (2004), Aiello et al. (2006), Copland et al. (2006b) and Antonelli et al. (2008)
|
| HMGI(Y) |
|
Adenoviral-antisense |
Scala et al. (2000) |
| Signaling pathways |
|
|
|
| EGFR |
|
Gefitinib |
Nobuhara et al. (2005) and Kurebayashi et al. (2006)
|
| EGFR/VEGFR |
|
AEE788 |
Kim et al. (2005a) and Hoffmann et al. (2007)
|
| EGFR |
|
Cetuximab |
Hoffmann et al. (2007) |
| BCR–ABL1, c-KIT |
|
Imatinib |
Podtcheko et al. (2003), Dziba & Ain (2004), Kurebayashi et al. (2006) and Rao et al. (2006)
|
| MAPKK(MEK) |
|
PD0325901; AZD6244 |
Leboeuf et al. (2008) and Liu & Xing (2008)
|
| CXCR4 |
|
siRNA; AMD3100 |
De Falco et al. (2007) |
| PTEN/AKT1 |
TZD (↑PTEN) |
TZD (↓pAKT1) |
Aiello et al. (2006) |
|
|
AKT1 inhibitor IV |
Hou et al. (2008) |
| JNK |
|
SP600125 |
Bulgin et al. (2006) |
| Farnesyl transferase |
|
Manumycin |
Xu et al. (2001) |
| Mitosis |
|
|
|
| Aurora kinases |
|
Aurora kinase inhibitor |
Sorrentino et al. (2005) |
|
VX-680 |
Arlot-Bonnemains et al. (2008) |
| Microtubules |
|
Paclitaxel; combretastatin 4P; valproic acid |
Ain et al. (1996), Dziba et al. (2002), Pushkarev et al. (2004), Voigt et al. (2005) and Catalano et al. (2007)
|
| Proliferation |
|
|
|
| OEATC-1 |
|
siRNA |
Mizutani et al. (2005) |
| RBBP4 |
|
siRNA |
Pacifico et al. (2007) |
| Oncolytic viruses |
|
ONYX-015; ONYX-411; mutant vaccinia; adenovirus HSV-TK and TP53-regulated |
Nagayama et al. (2001), Kitazono et al. (2002), Portella et al. (2002), Libertini et al. (2007), Lin et al. (2007, 2008) and Reddi et al. (2008)
|
|
Etoposide |
Antonelli et al. (2008) |
| Cell cycle |
|
|
|
| Cell cycle |
|
Gemcitabine |
Voigt et al. (2000) |
| Cyclins |
|
CCND1 siRNA; Imatinib; plitidepsin |
Podtcheko et al. (2003), Bravo et al. (2005) and Lee et al. (2008)
|
| CDK inhibitors |
TP53 adenovirus |
|
Blagosklonny et al. (1998), Aiello et al. (2006) and Copland et al. (2006b)
|
| BMP7 |
|
Franzen & Heldin (2001) |
| TZDs |
siRNA; mithramycin |
Podtcheko et al. (2003) and Bonofiglio et al. (2008)
|
| Apoptosis |
|
|
|
| IAPs |
|
siRNA; Smac |
Tirro et al. (2006) |
| NF-κB |
|
DHMEQ |
Meng et al. (2008) |
| IGF1 |
|
aIR3 antibody |
Poulaki et al. (2002) |
| DJ-1 |
|
siRNA |
Zhang et al. (2008) |
| PPARG |
TZD |
|
Aiello et al. (2006) and Copland et al. (2006b)
|
| EGFR/VEGFR |
|
AEE788 |
Kim et al. (2005a) |
| BCR–ABL1; c-KIT |
|
Imatinib |
Kurebayashi et al. (2006) |
| Aurora kinase |
|
VX-680 |
Arlot-Bonnemains et al. (2008) |
| Integrin-linked kinase |
|
QLT0267 |
Younes et al. (2005) |
| LCN2 |
|
siRNA |
Iannetti et al. (2008) |
| Polo-like kinase 1 |
|
siRNA |
Salvatore et al. (2007) |
| DUSP26 |
|
siRNA |
Yu et al. (2007) |
| Migration |
|
|
|
| Autotaxin |
Autotaxin |
IL1B,IL4,TGFB1 |
Kehlen et al. (2004) |
| VEGFR2 |
|
VEGFR2 inhibitor1 |
Balthasar et al. (2008) |
| Protein degradation |
|
|
|
| Proteasomes |
|
Bortezomib |
Mitsiades et al. (2006) and Conticello et al. (2007)
|
| Epigenetic |
|
|
|
| Histone acetylation |
|
Valproic acid; depsipeptide |
Kitazono et al. (2001), Catalano et al. (2006, 2007) and Xing (2007)
|
| Methylation |
|
5-aza-dCR |
Husmark et al. (1999) and Schagdarsurengin et al. (2002, 2006)
|
