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. Author manuscript; available in PMC: 2010 Feb 27.
Published in final edited form as: IEEE Rev Biomed Eng. 2008 Dec 16;1(1):75–93. doi: 10.1109/RBME.2008.2008241

Fig. 12.

Fig. 12

Examples of microfluidic gradient generators. (a) Flow-based dynamic gradient generator. Microchannels are used to mix streams in varying dilutions and brought together with laminar flow to form a gradient across the channel width [85]. (Reproduced by permission of the MRS Bulletin, 2005, characterized in [86].) (b) Gradient generator without flow. A concentration source and sink are connected via a microchannel using polyester membranes to facilitate cell loading and eliminate transient flow that could disturb the concentration profile [87]. (Figure reproduced by permission of The Royal Society of Chemistry, 2006.)