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Non-hematologic criteria for dose delay and dose modification of sorafenib (except for skin toxicity)#
| Grade | Dose Delay | Dose Modification |
|---|---|---|
| Grade 0-2 | Treat on time | No Change |
| Grade 3 | Delay* until ≤ Grade 2 | Decrease one dose level^ |
| Grade 4 |
#: Also excludes nausea/vomiting that has not been premedicated, and diarrhea.
*: If no recovery after 30-day delay, treatment will be discontinued.
^: If more than 2 dose reductions are required, treatment will be discontinued.
