Table 4.

Procedure for hypertension emerged by sorafenib treatment

Grade	Management/Next Dose
Grade 1	Consider increased BP monitoring
Grade 2 Asymptomatic and diastolic BP < 110 mm Hg	Begin anti-hypertensive therapy and continue the agent
Grade 2 Symptomatic/persistent or diastolic BP ≥ 110 mmHg or	1. Agent should be held until symptoms resolve and diastolic BP ≤ 100 mmHg; also treat patient with anti-hypertensives and when agent is restarted, reduce by 1 dose level.*
Grade 3	2. If diastolic BP not controlled (≤ 100) on therapy, reduce another dose level.^
Grade 4	Discontinue protocol therapy

*: May be able to resume full dose later.

^: Patients requiring > 2 dose reductions should go off protocol therapy.