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. Author manuscript; available in PMC: 2011 Feb 23.
Published in final edited form as: Biochemistry. 2010 Feb 23;49(7):1364–1376. doi: 10.1021/bi901135x

Figure 3.

Figure 3

A dark-quenched activatable MMP-13 probe. A) The molecular surface of human MMP-13 and the modeled binding pockets of the MMP-13 imaging probe. Arrow and italics indicate the cleavage site. B) Schematic diagram of activation process. C) In vivo imaging of overexpressed MMP-13 in normal, six and eight week osteoarthritis (OA)-induced cartilages 1 h after intracartilage-injection of the MMP-13 imaging probe. Arrows; dotted line (normal) and solid line (OA). Modified with permission from ref. 86. Copyright 2008, American Chemical Society.

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