Table 1.
A selective list of the radiolabeled peptide probes already investigated in human studies.
| Target receptor | Peptide probe | Condition | Comments | Ref. |
|---|---|---|---|---|
| SSTr | 111In-DTPA-octreotide | Neuroendocrine tumors | Approved | |
| DOTA-TOC | Neuroendocrine tumors | Clinical study | 29 | |
| DOTA-TATE | Neuroendocrine tumors | Clinical study | 29 | |
| 18F-[Gluc-Lys]-TOCA | Neuroendocrine tumors | Clinical study | 31 | |
| Integrin | 18F-galacto-RGD | Head and neck cancer | Clinical study | 38 |
| 18F-AH111585 | Metastatic breast cancer | Phase I trial | 39 | |
| 18F-RGD-K5 | Various cancers | Clinical study | ||
| 18F-FPPRGD2 | eIND | |||
| GRPr | 99mTc-RP-527 | Breast cancer | Clinical study | 47 |
| 68Ga-BZH3 | Gastrointestinal stromal tumor | Clinical study | 51 | |
| GLP-1r | 111In-[DTPA-Lys40]- Exendin-4 | Insulinoma | Clinical study | 66 |
| NTr | 99mTc-NT-XI | Pancreatic adenocarcinoma | Clinical study | 73 |