Table 1.
Body weight, fasting blood glucose, fasting serum insulin and serum insulin after clamp experiments of ovariectomized animals (O), sham surgery animals (intact) (C) and ovariectomized animals treated with 17β-estradiol (E). Mean ± standard error of the mean for seven animals
| 0 Months | 6 Months | 12 Months | 18 Months | 24 Months | ||
|---|---|---|---|---|---|---|
| Body weight (g) | C | 276.26 ± 3.49 * | 321.71 ± 8.45 * | 350.59 ± 7.56 * | 382.59 ± 9.65 * | 392.48 ± 6.79 |
| O | 274.06 ± 2.85 * | 355.67 ± 9.00 * | 379.00 ± 7.66 * | 457.6 ± 12.89 * | 488.33 ±7.80 | |
| E | 279.5 ± 1.97 * | 310.86 ± 8.78 * | 345.4 ± 8.77 * | 363.43 ± 14.39 * | 370.67 ± 8.16 | |
| Intramonth comparisons | O vs C,E | O vs C,E | C vs O, E; O vs E | C vs O, E; O vs E | ||
| Fasting blood glucose (mg/dl) | C | 94.26 ± 3.26 | 93.70 ± 3.62 | 92.53 ± 2.71 | 94.65 ± 4.21 | 95.55 ± 3.16 |
| O | 94.23 ± 3.17 | 92.66 ± 4.52 | 90.50 ± 5.38 | 95.20 ± 4.40 | 97.16 ± 3.89 | |
| E | 95.25 ± 4.23 | 88.00 ± 4.02 | 96.80 ± 9.72 | 99.71 ± 4.27 | 93.16 ± 3.49 | |
| Fasting serum insulin (ng/ml) | C | 0.95 ± 0.10 | 1.55 ± 0.12 | 1.95 ± 0.20 * | 2.87 ± 0.13 * | 3.45 ± 0.27 |
| O | 0.91 ± 0.12 * | 3.74 ± 0.18 * | 2.04 ± 0.12 * | 3.60 ± 0.16 * | 3.29 ± 0.15 | |
| E | 0.90 ± 0.06 | 0.97 ± 0.03 | 1.37 ± 0.13 | 1.46 ± 0.12 | 1.60 ± 0.10 | |
| Intramonth comparisons | O vs C,E | O vs C,E | O vs C,E; C vs E | E vs C,O | ||
| Serum insulin after clamp experiments (ng/ml) | C | 6.21 ± 0.30 * | 9.98 ± 0.7 * | 11.25 ± 1.35 * | 15.83 ± 1.23 * | 18.74 ± 1.21 |
| O | 5.98 ± 0.63 * | 15.01 ± 0.50 * | 18.03 ± 0.61 * | 26.70 ± 0.67 * | 29.78 ± 0.84 | |
| E | 5.73 ± 0.84 * | 12.42 ± 0.25 * | 15.44 ± 0.69 * | 21.31 ± 0.96 * | 24.01 ± 0.54 | |
| Intramonth comparisons | C vs O, E; O vs E | C vs O, E; O vs E | C vs O, E; O vs E | C vs O, E; O vs E | ||
* P ≤ 0.05 (month vs next month)