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. Author manuscript; available in PMC: 2010 Apr 28.
Published in final edited form as: Circulation. 2009 Apr 13;119(16):2161–2169. doi: 10.1161/CIRCULATIONAHA.108.815803

Figure 3. VSMC-selective PPARγ deletion caused enhanced sensitivity to β2-AdR agonists in vivo.

Figure 3

Figure 3

Figure 3

All tracing BP data were collected as described in supplemental methods, and are shown as one representative mice of 6 performed in each group. Agonists and/or antagonist were infused (indicated by an arrow) at a constant rate of 2 µl/min via jugular vein as indicated time. (A) 10−5 mol/L norepinephrine (NE) infusion increased blood pressure in LC mice. (B) 10−5 mol/L NE infusion in SMPG KO mice caused an initial increase in BP returning to baseline levels after 3 minutes infusion. (C) Co-infusion of 10−7 mol/L propranolol with 10−5 mol/L NE elevated BP in LC mice, (D) but completely blocked the reduction in BP in SMPG KO mice. (E) Terbutaline of 10−6 mol/L infusion did not affect BP in LC mice, (F) but lowered BP in SMPG KO mice.