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Human GSTA4-4 active site. GSTA4-4 is shown in complex with 3S,4R-GSDHN (3IK7, blue ligand). The conserved G-site is toward the lower half of the figure with Y9 shown in cyan. The 4-hydroxyl group is orientated toward R15 while the aldehyde-derived hydroxyl is in proximity of Y212 at the bottom of the H-site. Other important active site residues are labeled and shown as spheres to illustrate the hydrophobic cavity.
