Table 2.
Association of Kidney Function with Adverse Cardiovascular Outcomes*
| Estimated Glomerular Filtration Rate (ml/min/1.73m2) | ||||
|---|---|---|---|---|
| ≥60 | 45–59 | 30–44 | <30 | |
| Atherosclerotic cardiovascular event** | ||||
| Number of events | 645 | 81 | 42 | 65 |
| Demographic adjusted | 1.0 | 1.73 (1.36–2.20) | 2.39 (1.73–3.32) | 2.85 (2.11–3.86) |
| Multivariable adjusted | 1.0 | 1.46 (1.15–1.86) | 2.03 (1.47–2.82) | 1.99 (1.46–2.70) |
| Heart failure | ||||
| Number of events | 228 | 45 | 25 | 79 |
| Demographic adjusted | 1.0 | 2.56 (1.83–3.57) | 3.13 (2.02–4.84) | 5.16 (3.73–7.13) |
| Multivariable adjusted | 1.0 | 2.17 (1.55–3.03) | 2.59 (1.67–4.01) | 3.58 (2.58–4.98) |
| Individual Outcomes | ||||
| Coronary disease | ||||
| Number of events | 385 | 55 | 26 | 37 |
| Demographic adjusted | 1.0 | 1.98 (1.48–2.66) | 2.60 (1.71–3.94) | 3.30 (2.21–4.93) |
| Multivariable adjusted | 1.0 | 1.65 (1.23–2.21) | 2.19 (1.45–3.33) | 2.31 (1.54–3.46) |
| Cerebrovascular disease | ||||
| Number of events | 178 | 17 | 8 | 16 |
| Demographic adjusted | 1.0 | 1.33 (0.80–2.23) | 1.60 (0.77–3.34) | 2.33 (1.27–4.26) |
| Multivariable adjusted | 1.0 | 1.17 (0.70–1.96) | 1.37 (0.66–2.85) | 1.66 (0.90–3.05) |
| Peripheral arterial disease | ||||
| Number of events | 87 | 10 | 8 | 13 |
| Demographic adjusted | 1.0 | 1.47 (0.75–229) | 2.71 (1.26–5.85) | 2.66 (1.33–5.33) |
| Multivariable adjusted | 1.0 | 1.32 (0.67–2.59) | 2.21 (1.02–4.80) | 1.88 (0.92–3.85) |
*
Adjusted estimates reported as hazard ratio (95% confidence interval); eGFR reported in ml/min/1.73m2. Demographic adjusted models control for age, sex, race, and albuminuria. Multivariable adjusted models control for age, sex, race, and time-updated hypertension, diabetes, lung disease, dyslipidemia, smoking, CD4 count, HIV viral load, antiretroviral therapy, and albuminuria.
**
Atherosclerotic cardiovascular event: composite outcome of coronary, cerebrovascular, and peripheral arterial disease.