Table 1.

Characteristics of the Patients and Test Results before and after Injection.^*

Patient No.	Age	Sex	Mutation	Nystagmus Frequency†				Anomalies on OCT‡				Visual Acuity								Visual Field
												ETDRS§				LogMAR Score¶
				Right		Left		Right		Left		Right		Left		Right		Left		Right		Left
				Before	After	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After
	yr				Hz																degree
1	26	F	Homozygote  p.Glu102Lys  c.304G→A	2.0	1.2	2.0	1.2	ND	ND	ND	ND	Hand  motion	20/1050‖	20/1040	20/1100	2.0	1.72‖	1.72	1.74	41	177	36	26
2	26	M	Homozygote  p.Glu102Lys  c.304G→A	1.0	0.9	1.0	0.9	EM	MH	ND	ND	Hand  motion	20/710‖	20/500	20/220	2.0	1.55‖	1.40	1.04	62	213	55	75
3	19	F	Homozygote  p.R234X  c.700C→T	1.5	1.4	1.37	1.1	ND	ND	ND	ND	20/640	20/290**	20/220	20/210	1.50	1.16**	1.05	1.03	147	210	203	160

^*EM denotes epiretinal membrane, ETDRS Early Treatment Diabetic Retinopathy Study, logMAR log₁₀ of the minimum angle of resolution, MH macular hole, ND not detectable, and OCT optical coherence tomography.

^†The frequency of nystagmus was measured from short videotaped sequences, and the significance of these results cannot be calculated.

^‡Measurements of precise retinal thicknesses by OCT varied because of the lack of fixation and the presence of nystagmus, so retinal thickness was estimated on some of the macular scans. However, OCT was useful in detecting structural anomalies, such as EM and MH.

^§The detection of hand motion corresponds to a visual acuity of a Snellen equivalent of <20/2000, according to ETDRS charts and letter counts.

^¶The logMAR score ranges from 0.00 to 2.00, with higher values indicating poorer vision.

^‖P<0.001.

^**P = 0.002.