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. 2009 Nov 25;29(47):14764–14769. doi: 10.1523/JNEUROSCI.4291-09.2009

Figure 4.

Figure 4.

CBD effects on CB1R and glutamate receptor expression in relation to cue-induced heroin-seeking behavior. a–c, CB1R RNA (a) and protein (b and c) levels in the NAc following either vehicle or CBD administration 24 h (1×) before the cue-induced drug-seeking session. d–f, mGluR5 RNA levels (d) and GluR1 protein levels (e and f). Data represent mean ± SEM; n = 4–8/group. NAc-c, NAc core; M/L-NAc-s, medial/lateral NAc shell; CP, caudate–putamen (dorsal striatum); SA, self-administration. *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle; #p < 0.01 versus heroin–vehicle.