Table 1.

Hepatic 8OHdG, TBARS, hydroperoxide, bile acid and triglyceride concentrations, and plasma ALT activity in Fxr-null mice

	Liver					Plasma
	8OHdG (ng/g liver)	TBARS (nmol MDA/g liver)	Hydroperoxide (µmol DCFein/g liver)	Bile acid (µmol/g liver)	Triglyceride (mg/g liver)	ALT (IU/L)
Control	4.1 ± 0.5	103 ± 31	2.29 ± 0.42	0.58 ± 0.35	20.9 ± 6.4	108 ± 54
ME3738	2.7 ± 0.5#	58 ± 9#	1.60 ± 0.10#	0.20 ± 0.11#	17.0 ± 4.1	42 ± 23#
CA	6.8 ± 1.5##	295 ± 108#	3.73 ± 0.54##	2.92 ± 0.89##	19.1 ± 8.8	266 ±89##
CA+ME3738	4.1 ± 0.7**	172 ± 28*	2.52 ± 0.58**	1.35 ± 0.51**	13.2 ± 4.3	158 ± 52*

Liver homogenate was prepared from Fxr-null mice fed the control, and 0.15% ME3738, 0.25% CA, or CA+ME3738 diet for 6 days. Hepatic 8OHdG concentrations were measured by ELISA. Hepatic TBARS and bile acid concentrations, and plasma ALT activity were measured by enzyme-colorimetric method. Hepatic hydroperoxide concentrations were measured as fluorescence of dichlorofluorescein-diacetate. Data are shown as mean ± S.D. (control; n=8, others; n=4).

^{#, ##}significantly different from the control group (p<0.05, p<0.01, respectively),

^{*, **}significantly different from CA group (p<0.05, p<0.01, respectively)