Table 3.
The correlations, represented by r (correlation coefficient) and P values, between the GeneChip® expressions (as signal log ratios) of the 38 significant probes (35 genes) and the functional hearing measurements of all mice of the present study
Symbol | ABR/3 kHz (r; P value) |
ABR/6 kHz (r; P value) |
ABR/12 kHz (r; P value) |
ABR/24 kHz (r; P value) |
ABR/32 kHz (r; P value) |
ABR/48 kHz (r; P value) |
DPOAE low freq. (r; P value) |
DPOAE mid freq. (r; P value) |
DPOAE high freq. (r; P value) |
---|---|---|---|---|---|---|---|---|---|
Probeset up-regulated with age/hearing loss | |||||||||
Bcl2 | 0.06; 0.71 | 0.04; 0.81 | 0.16; 0.48 | 0.08; 0.64 | 0.12; 0.45 | 0.07; 0.68 | 0.30; 0.06 | 0.21; 0.19 | 0.19; 0.25 |
Bcl2a1a | 0.20; 0.21 | 0.36; 0.021* | 0.40; 0.011* | 0.32; 0.048* | 0.36; 0.021* | 0.355; 0.025* | 0.53; 0.0004*** | 0.44; 0.0042** | 0.38; 0.016* |
Bcl2a1a | 0.61; < 0.0001*** | 0.75; < 0.0001*** | 0.69; < 0.0001*** | 0.73; < 0.0001*** | 0.67; < 0.0001*** | 0.76; < 0.0001*** | 0.71; < 0.0001*** | 0.77; < 0.0001*** | 0.75; < 0.0001*** |
Bcl2l1 | 0.17; 0.28 | 0.23; 0.16 | 0.12; 0.47 | 0.21; 0.18 | 0.12; 0.45 | 0.15; 0.34 | 0.31; 0.051 | 0.32; 0.042* | 0.31; 0.049* |
Bcl2l11 | 0.18; 0.27 | 0.33; 0.036* | 0.34; 0.029* | 0.32; 0.044* | 0.249; 0.12 | 0.24; 0.134 | 0.335; 0.035* | 0.29; 0.069 | 0.185; 0.25 |
Bcl2l11 | 0.046; 0.78 | 0.148; 0.36 | 0.13; 0.419 | 0.123; 0.45 | 0.104; 0.53 | 0.086; 0.597 | 0.217; 0.179 | 0.16; 0.322 | 0.086; 0.598 |
Bcl3 | 0.155; 0.34 | 0.23; 0.148 | 0.211; 0.19 | 0.337; 0.03* | 0.318; 0.045* | 0.292; 0.068 | 0.357; 0.024* | 0.364; 0.021* | 0.326; 0.04* |
Mcl1 | 0.254; 0.11 | 0.26; 0.1 | 0.147; 0.365 | 0.183; 0.259 | 0.131; 0.419 | 0.167; 0.303 | 0.27; 0.092 | 0.26; 0.105 | 0.22; 0.171 |
Casp1 | 0.014; 0.93 | 0.133; 0.41 | 0.102; 0.53 | 0.182; 0.26 | 0.156; 0.34 | 0.1899; 0.24 | 0.123; 0.45 | 0.143; 0.38 | 0.129; 0.428 |
Casp9 | 0.283; 0.08 | 0.3; 0.057 | 0.32; 0.044* | 0.22; 0.168 | 0.322; 0.043* | 0.284; 0.076 | 0.321; 0.044* | 0.308; 0.053 | 0.272; 0.089 |
Casp4/11 | 0.179; 0.27 | 0.35; 0.028* | 0.495; 0.001** | 0.451; 0.004** | 0.6; < 0.0001*** | 0.6; < 0.0001*** | 0.51; 0.0009*** | 0.472; 0.002** | 0.497; 0.001** |
Apaf1 | 0.158; 0.33 | 0.37; 0.018* | 0.456; 0.003** | 0.385; 0.014* | 0.392; 0.012* | 0.349; 0.027* | 0.44; 0.0044** | 0.44; 0.0044** | 0.42; 0.007** |
P53 | 0.055; 0.74 | 0.229; 0.16 | 0.345; 0.029* | 0.321; 0.043* | 0.289; 0.07 | 0.211; 0.19 | 0.365; 0.02* | 0.366; 0.02* | 0.362; 0.022* |
Jun | 0.176; 0.28 | 0.049; 0.77 | 0.013; 0.94 | 0.01; 0.95 | 0.142; 0.38 | 0.22; 0.17 | 0.042; 0.799 | 0.068; 0.68 | 0.105; 0.52 |
Map3k1 | 0.24; 0.138 | 0.35; 0.027* | 0.397; 0.011* | 0.323; 0.042* | 0.419; 0.007** | 0.51; 0.0009*** | 0.246; 0.125 | 0.271; 0.091 | 0.252; 0.116 |
Map3k11 | 0.115; 0.48 | 0.183; 0.26 | 0.113; 0.488 | 0.192; 0.235 | 0.216; 0.18 | 0.203; 0.21 | 0.333; 0.036* | 0.238; 0.14 | 0.206; 0.202 |
Dusp9/Mkp4 | 0.27; 0.089 | 0.43; 0.006** | 0.47; 0.0023** | 0.42; 0.0069** | 0.489; 0.001** | 0.497; 0.001** | 0.48; 0.0016** | 0.40; 0.0097** | 0.367; 0.02* |
Atf3 | 0.423; 0.0065** | 0.379; 0.016* | 0.426; 0.0062** | 0.426; 0.0062** | 0.518; 0.0006*** | 0.547; 0.0003*** | 0.447; 0.0039** | 0.473; 0.0021** | 0.493; 0.0012** |
Hrk | 0.219; 0.17 | 0.395; 0.01* | 0.389; 0.013* | 0.325; 0.041* | 0.369; 0.019* | 0.379; 0.016* | 0.495; 0.001** | 0.458; 0.003** | 0.464; 0.0026** |
Tnfrsf12a | 0.44; 0.004** | 0.5; 0.001** | 0.46; 0.0026** | 0.49; 0.0012** | 0.42; 0.0076** | 0.44; 0.0043** | 0.52; 0.0007*** | 0.46; 0.0028** | 0.41; 0.0087** |
Tnfrsf12a | 0.5; 0.001** | 0.5; 0.0003*** | 0.47; 0.002** | 0.498; 0.001** | 0.43; 0.0056** | 0.47; 0.0022** | 0.55; 0.0002*** | 0.49; 0.0011** | 0.44; 0.0041** |
Tnfsf13b | 0.2; 0.199 | 0.34; 0.011* | 0.43; 0.0057** | 0.46; 0.0029** | 0.52; 0.0007*** | 0.47; 0.0023** | 0.45; 0.0036** | 0.446; 0.004** | 0.487; 0.0014** |
Rela | 0.056; 0.73 | 0.077; 0.64 | 0.055; 0.74 | 0.113; 0.49 | 0.002; 0.99 | 0.082; 0.62 | 0.126; 0.44 | 0.156; 0.39 | 0.103; 0.53 |
Nfkbia | 0.31; 0.054 | 0.237; 0.14 | 0.25; 0.12 | 0.27; 0.092 | 0.316; 0.047* | 0.37; 0.019* | 0.35; 0.026* | 0.359; 0.023* | 0.301; 0.059 |
Nfkbib | 0.174; 0.28 | 0.27; 0.097 | 0.235; 0.145 | 0.24; 0.136 | 0.166; 0.31 | 0.136; 0.403 | 0.302; 0.058 | 0.26; 0.104 | 0.218; 0.177 |
Cflar/Cflip | 0.09; 0.583 | 0.124; 0.45 | 0.249; 0.122 | 0.225; 0.163 | 0.355; 0.025* | 0.355; 0.025* | 0.28; 0.077 | 0.237; 0.142 | 0.23; 0.153 |
Cd40 | 0.33; 0.036* | 0.5; 0.001** | 0.47; 0.0022** | 0.47; 0.0024** | 0.223; 0.166 | 0.317; 0.046* | 0.34; 0.032* | 0.41; 0.0088** | 0.344; 0.0297* |
C1qtnf3 | 0.224; 0.16 | 0.159; 0.33 | 0.097; 0.55 | 0.1; 0.95 | 0.003; 0.99 | 0.053; 0.75 | 0.22; 0.17 | 0.224; 0.16 | 0.232; 0.15 |
C1qtnf5 | 0.098; 0.55 | 0.205; 0.21 | 0.305; 0.056 | 0.387; 0.014* | 0.417; 0.008** | 0.315; 0.048* | 0.426; 0.006** | 0.392; 0.012* | 0.339; 0.032* |
Cycs | 0.054; 0.11 | 0.029; 0.86 | 0.065; 0.69 | 0.0005; 0.99 | 0.102; 0.53 | 0.129; 0.429 | 0.09; 0.582 | 0.044; 0.786 | 0.012; 0.943 |
Probeset down-regulated with age/hearing loss | |||||||||
Bcl2l2 | 0.245; 0.13 | 0.41; 0.009** | 0.48; 0.0019** | 0.445; 0.004** | 0.48; 0.0019** | 0.53; 0.0004*** | 0.49; 0.0015** | 0.498; 0.0011** | 0.455; 0.0032** |
Bcl7b | 0.159; 0.33 | 0.247; 0.12 | 0.393; 0.012* | 0.44; 0.0049** | 0.467; 0.002** | 0.449; 0.0037** | 0.378; 0.016* | 0.398; 0.011* | 0.429; 0.0058** |
Casp7 | 0.065; 0.69 | 0.238; 0.14 | 0.282; 0.078 | 0.299; 0.061 | 0.287; 0.072 | 0.204; 0.207 | 0.352; 0.026* | 0.264; 0.100 | 0.218; 0.177 |
Slc25a14 | 0.46; 0.003** | 0.5; 0.0008*** | 0.5; 0.0009*** | 0.52; 0.0006*** | 0.57; 0.0001*** | 0.65; < 0.0001*** | 0.45; 0.0034** | 0.49; 0.0014** | 0.48; 0.0016** |
Capn2 | 0.41; 0.009** | 0.5; 0.0009*** | 0.56; 0.0002*** | 0.5; 0.001** | 0.43; 0.005** | 0.44; 0.004** | 0.51; 0.0007*** | 0.49; 0.0014** | 0.38; 0.0153* |
Capn7 | 0.167; 0.3 | 0.17; 0.29 | 0.083; 0.61 | 0.113; 0.49 | 0.02; 0.9 | 0.048; 0.77 | 0.199; 0.22 | 0.187; 0.248 | 0.167; 0.31 |
Mapk10 | 0.256; 0.11 | 0.44; 0.004** | 0.46; 0.0076** | 0.49; 0.0015** | 0.456; 0.003** | 0.397; 0.011* | 0.436; 0.0049** | 0.408; 0.009** | 0.363; 0.021* |
Traf3 | 0.24; 0.13 | 0.33; 0.038* | 0.271; 0.09 | 0.278; 0.083 | 0.266; 0.097 | 0.284; 0.076 | 0.268; 0.094 | 0.283; 0.077 | 0.254; 0.114 |
0.01 < P < 0.05
0.001 <P <0.01
0.0001 < P < 0.001